OVERALL ROLE OBJECTIVE:
The Scientist/Senior Scientist with Stem Cell Biology expertise will work within the Product Development Team applying field-specific knowledge and experience to achieve set the program objectives. The post holder will design, perform and analyse experiments as well as initiate new projects based on TCB’s γδ T cell platform. In particular, the post-holder will contribute to better understanding of γδ T cell ontogeny and how this can be applied to generate more efficacious γδ T cell-based therapies.
To successfully achieve the project objectives, the post-holder will be expected to apply expertise across a number of practical skills, including stem cell biology, immunology, molecular biology, primary cell culture, flow cytometry and cell-based assays. The post holder will be an excellent team player, will be aligned with company values and goals, and will be able to work independently. They will be proactive and work flexibly to deliver on objectives.
Other responsibilities will include support of other departments as required, and contribution to general lab maintenance compliant with GMP procedures.
RESPONSIBILITIES INCLUDE BUT ARE NOT LIMITED TO:
• Perform cell culture of pluripotent cells, primary immune cells, generation and maintenance of established cell lines.
• Perform differentiation of pluripotent cells to various cell lineages.
• Lead in the characterisation of differentiated cells by flow cytometry and qPCR.
• Perform functional cell-based assays.
• Work independently and with the stem cell team to initiate projects, to analyse data, to draw appropriate conclusions and decide upon next steps.
• Ensure work is performed in accordance with the company’s quality assurance and health and safety policies including the provision of COSHH/BIOCOSHH/Risk assessments.
• Maintain documentation to appropriate quality standards, including, but not limited to, laboratory notebooks, standard operating procedures, COSHH/BIOCOSHH assessments and risk assessments.
• Carry out literature reviews /collate information to identify information useful for the development of novel assays or the improvement of current processes.
• Provide support to other departments within the company.
• Contribute to written documentation including SOPs, publications and patent applications.
QUALIFICATIONS, SKILLS & EXPERIENCE:
• Degree in stem cell/cell biology or equivalent experience. PhD level qualification is advantageous.
• Extensive experience in cell culture, cell-based assays and flow cytometry is essential.
• Experience in handling human ES/iPS cells including thawing, passaging, colony picking, cryopreservation and differentiation.
• Experience in molecular biology techniques (e.g. RNA isolation, qPCR).
• An interest in cell-based therapies and their application to treat cancer and viral/bacterial infections.
• Ability to work under pressure, as part of a team with a “can do” attitude.
• Computer skills (Word, Excel, Powerpoint, GraphPad Prism and FlowJo)
• Strong presentation skills
• Excellent written/oral communication and interpersonal skills
• Thorough approach and high attention to detail
• Strong time management and organisational skills
If you are looking to work within a challenging, dynamic, and rewarding environment, then TCB represents an excellent career move.
This is an opportunity to be part of a growing, ambitious business where people development is critical to future success. As we continue to expand, there will be career opportunities on a truly global scale.
TCB is an Equal Opportunity Employer. We welcome and encourage diversity in the workplace.
Together with a competitive salary, we offer a comprehensive range of benefits and an excellent working environment.